Martín Perfecto de Cos (1800–1854) was a 19th-century Mexican general. He was married to Lucinda López de Santa Anna, sister of Antonio López de Santa Anna.
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Cós was born in Vera Cruz in the year 1800, the son of an attorney. He attained the rank of General in the Mexican Army and took part in the campaign against the rebellious state of Coahuila y Texas in the 1835–36 Texas War of Independence from which the Republic of Texas arose.
Cos was appointed commander of military forces in Texas in July 1835 and was sent there to disarm any rebellious citizens. He arrived in Texas on September 21, 1835 with 300 soldiers. Cos proceeded to the town of Goliad on October 1, then moved on to San Antonio de Béxar. Cos ordered the arrest of William B. Travis and any other rebel leaders. Once in San Antonio (Siege of Béxar), Cos was assailed by Texian forces under the leadership of Stephen F. Austin. The town was put under siege by the Texan army. After a 56-day siege of the town and Alamo mission, on December 9, Cos surrendered the town of San Antonio and weapons to the Texians then proceeded to leave Texas. Cos and his men were allowed their muskets for protection and one four-pound cannon. Mexican losses during the siege were about 150. On his way south, Cos met up with Santa Anna's forces at Laredo marching north to put down the rebellion.
Cos returned to San Antonio and led a column of 300 soldiers against the northwest corner of the Alamo on March 6, 1836. Eventually Cos' soldiers overran the Alamo's north wall.
On April 21, 1836, Cos arrived with over five hundred reinforcements for Santa Anna shortly before the Battle of San Jacinto. He was taken prisoner on April 24, after his battalion was smashed and routed by a combined attack by Texas volunteers under Colonels Sidney Sherman and Edward Burleson.
Cos was in charge of the garrison at Tuxpan, but did not play a significant role in the fighting with the United States Army.